Screw less designed Smart Blotter, so called Vacuum Blotter, slot blotter, equipped with unique edge designed sample wells that offer an effective sealing to prevent cross-contamination between wells, and producing high quality blots. Vacuum provided by the aspirator pump, give a simple and convenient way for screening recombination clone, protein, and DNA / RNA. Up to 700 μl per well volume for sample loading with 8-channel pipette applicable, results are easily qualified through densitometer scanning. Main body is autoclavable for extreme conditions.